RAS PhysicsПоверхность. Рентгеновские, синхротронные и нейтронные исследования Journal of Surface Investigation. X-Ray, Synchrotron and Neutron Techniques

  • ISSN (Print) 1028-0960
  • ISSN (Online) 3034-5731

Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR-XRF Method

PII
S30345731S1028096025020154-1
DOI
10.7868/S3034573125020154
Publication type
Article
Status
Published
Authors
Volume/ Edition
Volume / Issue number 2
Pages
124-130
Abstract
Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, Cd) in patients with two pathologies, lymphoma and leukemia, is considered.
Keywords
рентгенофлуоресцентный анализ синхротронное излучение следовые элементы биопсийный материал красный костный мозг гемобластозы лимфомы острый лейкоз персонифицированная медицина
Date of publication
27.11.2024
Year of publication
2024
Number of purchasers
0
Views
47

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